CQU7027 – BIOINORGANIC AND INORGANIC MEDICINAL CHEMISTRY

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LEVEL: Master and Doctorate

CREDITS: 4

MAIN TOPICS:

General principles and fundamentals. Study of bioinorganic systems: structural characterization and their action in biological systems. Model compounds for bioinorganic systems. General aspects of drug action. Fundamentals of drug action mechanisms. Discovery, rational planning and development of new drugs. Fundamentals of inorganic medicinal chemistry, essential elements, bioisosterism. Identification and molecular modification of prototypes, studies of promising systems and application in the pharmaceutical industry.

RECOMMENDED LITERATURE:

KAIM, W.; SCHWERDERSKI, B. Bioinorganic Chemistry: inorganic elements in the chemistry of life. 2nd ed. New York: John Wiley & Sons, 2013.

BERTINI, I.; GRAY, H. B.; LIPPARD, S. J.; VALENTINE, J. S. Bioinorganic Chemistry. Sausalito, CA: University Science Books, 1994.

LIPPARD, S. J.; BERG, J. M. Principles of Bioinorganic Chemistry. Sausalito, CA: University Science Books, 1994.

DA SILVA, J. J. R. F.; WILLIAMS, R. J. P. The Biological Chemistry of the Elements: the inorganic chemistry of life. 2nd ed. Oxford: Oxford University Press, 2001.

QUE JR., L. Physical Methods in Bioinorganic Chemistry: spectroscopy and magnetism. Sausalito, CA: University Science Books, 2000.

SUSLICK, K. S. (Ed). Comprehensive Supramolecular Chemistry. v. 5. New York: Elsevier Science, 1996.

ATKINS, P. W.; OVERTON, T.; ROURKE, J.; WELLER, M.; ARMSTRONG, F. Inorganic Chemistry. 5th ed. New York: W. H. Freeman and Company, 2010.

CRICHTON, R. Biological Inorganic Chemistry. 2nd ed. Amsterdam, Elsevier, 2012.

PATRICK, G. L. An introduction to Medicinal Chemistry. 5th ed. Oxford: Oxford University Press, 2013.

BARREIRO, E. J.; FRAGA, C. A. M. Química Medicinal. 3. ed. Rio de Janeiro: Artmed, 2015.

SESSLER, J. L.; COCTROW, S. R.; McMURRY, T. J.; LIPPARD, S. J. Medicinal Inorganic Chemistry. New York: American Chemical Society, 2005.

STORR, T. Ligand Design in Medicinal Inorganic Chemistry. New York: Wiley, 2014.

ALESSIO, E.; FARRER, N. J.; SADLER, P. J. Medicinal Inorganic Chemistry: state of the art, new trends, and a vision of the future. New York: Wiley, 2011.